Anti-inflammatory Effects of Copaxone on the Level of Adhesion Molecule Expression Patterns under Short- and Long-term Treatment
نویسندگان
چکیده
Introduction/Objectives: To analyse the infl uence of shortand long-term glatiramer acetate (GA) treatment on expression patterns of cell surfacebound adhesion molecules (AM) on peripheral blood mononuclear cells (PBMC) from patients with relapsing remitting multiple sclerosis (RRMS). BACKGROUND: GA is baseline therapy for the treatment of RRMS. It is known to reduce relapse frequencies and to delay disease progression but the exact mechanisms of action remain elusive. Here, we investigate AM expression levels on PBMC from MS patients under short-and long-term GA therapy and from healthy controls.
منابع مشابه
Effect of Tribulus Terrestris L. on Expression of ICAM-1, VCAM-1, E-Selectin and Proteome Profile of Human Endothelial Cells In-Vitro
Background: Atherosclerosis is a chronic inflammation that interferes with blood arteries functions due to the accumulation of low density lipids and cholesterol. Objective: To investigate the effect of aqueous extract and saponin fraction of Tribulus terrestris L. (TT) on the proteome and expression of intracellular adhesion molecule-1 (ICAM-1), vascu...
متن کاملEffects of Short Term Oral Administration of Curcumin on Achilles Tendon Healing in Rats
Objective- Tendon healing, in terms of histologic and functional characteristics, is always inferior to its normal level due to the poor vascularity and low metabolic rate. Curcumin possesses anti-inflammatory, anti-oxidant and healing effects. This study aimed to investigate effects of curcumin on Achilles tendon experimental injury using histopathology, biomechanical and functional evaluation...
متن کاملThe effect of microRNA-125 on the adhesion molecule expression of integrin beta2 and adhesive determination of endothelial cells isolated from human aorta to monocyte
Background: The immune-mediated responses in vascular cells may include the increased expression of endothelial adhesion molecules, leukocyte rolling and infiltration, cellular lipid dysregulation and vascular smooth muscle cells (VSMCs) differentiation. Investigating the cellular and molecular events involved in the rolling process is useful for treatment or prevention of the vessel stenosis es...
متن کاملFluvoxamine inhibits some inflammatory genes expression in LPS/stimulated human endothelial cells, U937 macrophages, and carrageenan-induced paw edema in rat
Objective(s): Fluvoxamine is a well-known selective serotonin reuptake inhibitor (SSRI); Despite its anti-inflammatory effect, little is known about the precise mechanisms involved. In our previous work, we found that IP administration of fluvoxamine produced a noticeable anti-inflammatory effect in carrageenan-induced paw edema in rats. In this study, we aimed to evaluate the effect of fluvoxa...
متن کاملPiperine pre-treatment has immunomodulatory effects in hippocampal local model of demyelination
Introduction: Inflammatory processes has an important role in the Multiple Sclerosis (MS)’s pathophysiology. Therefore, hampering the inflammatory factors could be an effective strategy in MS treatment. Piperine (the main alkaloid of black piper) has immunomodulatory and anti-inflammatory properties. In this study the pre-treatment effects of piperine on the gene expression level of inflammator...
متن کامل